Endocrine Abstracts

Introduction: C1q/TNF-related protein-3 (CTRP-3) is a newly discovered adipokine with anti-inflammatory impact on monocytes by down-regulation of pro-inflammatory cytokines, e.g. interleukine 6 (IL6) and tumor necrosis factor alpha (TNF-alpha), in both adipocytes and monocytes. So far it is unclear which kind of interactions and molecular mechanisms are underlying the observed effects. Our aim is to characterize the differential effects of the globular and the collagenous doma...